August, 1999

Dear Society Members:

Greetings! I hope you are all having a pleasant summer despite the heat in some parts of the country.

The Society Symposium at the USCAP in San Francisco, on March 21st, was a great success. The Symposium topic was Myelodysplastic Syndromes and Related Disorders. The Symposium attracted a very large audience (estimated by USCAP at 650), and the overall audience ratings were very high. We are greatly indebted to Jim Vardiman and David Head for organizing it, and to Dick Brunning, Jim, David, Kathy Foucar, Cheryl Willman, and our guest speakers, Janet Rowley and Kevin Shannon for their excellent presentations. The remarkable progress experienced over the last ten years in understanding the biology and genetics of myeloid disorders has removed at least some of the mystery from this difficult diagnostic area. We look forward to additional progress in the near future.

At the Society business meeting, the members observed a moment of silence for Kevin Salhaney of the University of Pennsylvania, Philadelphia, who died suddenly last year. A scholarship fund has been set up in his name at the University of Pennsylvania; members interested in making donations may contact the Division of Anatomic Pathology at Hospital of the University of Pennsylvania. The Society has made a donation in the amount of $250.00.

The Pathologist-in-Training Award for 1999 was awarded to Dr. Keith Izban for his study entitled "Inhibition of NF kB Induced Apoptosis in Hodgkin's Disease Cell Lines is Independent of the Cell Death Protease CPP32/CASPASE 3." Please join me in congratulating Dr. Izban for his excellent presentation.

As you know the Society Executive Committee has decided to change its journal affiliation from American Journal of Surgical Pathology to Modern Pathology. The details of this transition were worked out in the Fall of 1998, and Modern Pathology became our official journal in January, 1999. In addition to listing the Society as a sponsoring society, the journal has appointed a member of the Society to the Editorial Board of the journal; this editor will assist in selecting reviewers and arbitrating disputes over hematopathology submissions to the journal. A separate Hematopathology section will not be provided, and the editor will not specifically be identified on the masthead as being the editor for Hematopathology. In this way we hope to avoid the controversy that surrounded the Hematopathology and GI sections in AJSP. The first editor from the Society is Peter Banks, and we thank him for taking on this responsibility.

The ASCP Companion Meeting in 1998, organized by LoAnn Peterson and Curt Hanson, attracted 68 attendees and received very favorable reviews. This year's Companion Meeting, to be held on Friday, September 24, 1999 in New Orleans, has been organized by Diane Farhi and LoAnn Peterson. The speakers are Judy Ferry (Extranodal lymphomas), Curt Hanson (Peripheral T-cell lymphomas in bone marrow), Rob McKenna (LGL/NK lymphoproliferative disorders) and Tim Greiner (Molecular consultation: PCR in the diagnosis of lymphoma).

Workshop reminders:

  1. The 2nd Joint Meeting with the SH and EAHP will occur in Barcelona, September 17 and 18, 1999, organized by Elias Campo. Those interested in attending should have already registered. A large number of excellent cases have been submitted and we look forward to an outstanding meeting.

  2. The next EAHP Workshop, the "Millennium Conference", will take place in London, May 8-11, 2000. All members should have received flyers with the second announcement and call for cases for this workshop. The meeting and workshop will focus on the B-cell follicle; with all the new developments in the biology and genetics of follicle center B cells and the multiplicity of lymphoid neoplasms that derive from these cells, it promises to be a very exciting event.

  3. SH Workshop, 2001: At the business meeting, I asked for volunteers for this workshop, which should be held in the late Spring or early Fall of 2001. So far only one proposal has been received; I encourage any other members who are interested in hosting a workshop to let me know ASAP. I am attaching a summary of the previous workshop topics, the guidelines for society workshops, and the space requirements. The host may propose the topic and the panel membership, subject to the approval of the SH President and Executive Committee. Dr. Steven Swerdlow has agreed to serve as meeting secretary, and will assist the host with advice based on previous experience.

The Executive Committees of the SH and EAHP have been discussing ways of more closely affiliating the two societies. Three proposals have been made and approved by the Executive Committees of both societies; they will need to be incorporated into our Bylaws and voted on at the 2000 business meeting. These proposals are:

  1. A member of the Executive Committee (EXCO) of each society will be a member of the Executive Committee of the other society. That is, each society will elect to its Executive Committee a representative from the EXCO of the other society. Several years ago, the SH approved an additional position on the EXCO for a member of the EAHP; however it was not specified that this member should be an EAHP EXCO member. The advantage of this change will be that there will be a direct line of communication between the EXCO's of the two societies.

  2. Both societies have agreed that members in good standing in one society may automatically be elected to membership in the other society, by presenting to the Secretary/Treasurer evidence of membership in good standing in the home society and by paying the dues required by the other society.

  3. Joint Workshops: After the year 2000 meeting of the EAHP, the societies have agreed that all future workshops will be officially "joint". They will continue to be organized by the local society, but the workshop panel will include two members of the other society. Registration and case submission will be open to all members; however, in order to encourage true joint membership, priority for case acceptance and reduced registration will be offered only to those who are joint members or members of the host/local society. We believe that this policy will maximize joint membership and participation in the workshops without creating a financial burden for the workshop organizers.

The Bylaws of the SH will be revised to incorporate the three changes that I described; the changes will be circulated prior to the next USCAP meeting, for a vote at the business meeting.

SH Symposium, 2000: Drs. Kathy Foucar and Tom Grogan have organized an excellent symposium on histiocytic and dendritic cell neoplasms. This will be held Sunday, March 26, 2000 from 1:30-5:00 PM. The speakers will be Elaine Jaffe, Larry Weiss, Tom Grogan, Ron Jaffe, Roger Warnke, and Diane Farhi. As with the myelodysplastic syndromes, it finally seems as though we are getting some grasp of these difficult neoplasms of histiocytic and dendritic cell origin, and the symposium should be very interesting and informative.

Dr. Eric Hsi has taken over responsibility for the cases of the quarter. Members with cases of interest, should contact Eric directly at the Cleveland Clinic Foundation, Department of Clinical Pathology, 9500 Euclid Avenue, #L-11, Cleveland, OH 44195-0002; e-mail: hsie@cesmtp@ccf.org.

I would like to call your attention to two publications resulting at least in part from Society efforts. First, the report of the Pittsburgh Workshop (1997) was published as a supplement to the American Journal of Clinical Pathology and Pathology Patterns in January, 1999 [AJSP,1999:111(1), Suppl 1, S12-S152]. This is a very useful and well-illustrated volume on extranodal hematologic proliferations and I highly recommend it both for members and their trainees. In addition, the Long Course proceedings from the USCAP meeting in 1998 were published as a special issue of Modern Pathology [Modern Pathology 1999;12(2)].

Finally - what in the world has happened to the WHO Classification? Fear not, work continues! As you will recall, a Clinical Advisory Committee meeting was held in the Fall of 1997; at that time there was considerable controversy over the myeloid leukemia classification. Extensive work since that time has resulted in a near-final version of a myeloid leukemia classification, and the report of the Clinical Advisory Committee meeting is now ready to be submitted to journals. It will be submitted (and hopefully published) simultaneously in Journal of Clinical Oncology, Annals of Oncology, The European Journal of Hematology, Modern Pathology, and Histopathology. In this way, we hope to reach as large as possible an audience of both oncologists, hematologists, and pathologists. The article will also be posted on the Society for Hematopathology website, which can be accessed at www.Dartmouth.edu/~nlevy/wwwx.html.

When the WHO effort is completed, there needs to be an ongoing mechanism for updating and revising the classification. The WHO does not officially engage in this type of activity, and I believe that it is imperative that the SH and EAHP set up some kind of ongoing joint committee that will periodically review and decide upon the need for updating the classification of hematologic malignancies. I hope that this can be a matter for discussion in the Executive Committees in the coming year. I encourage any members who have thoughts on this subject to e-mail me or fax me with your suggestions.

SH member honored: The publication Science Watch (tracking trends and performance in basic research) listed Society member and former president Elaine Jaffe among the top ten most cited researchers in Oncology. Our congratulations to Elaine!

I look forward to seeing as many of you as possible at the Barcelona Workshop, and hopefully all of you at the USCAP meeting in New Orleans and our Symposium on March 26th.

With best wishes,

Yours truly,

Nancy L. Harris, M.D.

 

SH and EAHP Workshop Topics

  1. SH Workshops

    • 1991: Hodgkin's Disease (San Antonio)
    • 1993: Low-grade B-cell Lymphoma (Toronto)
    • 1995: Lymphoproliferative Disorders in Immune Deficiencies (Duarte)
    • 1997: Extranodal Lymphomas (Pittsburgh)

  2. EAHP Workshops

    • 1986: Large-cell Lymphomas (Brussels)
    • 1988: Extranodal Lymphomas (Geneva)
    • 1990: Thymic Neoplasms and Immune Deficiencies (Wurzburg)
    • 1992: Histiocytic Disorders (Bologna)
    • 1994: Hodgkin's Disease (Toledo)
    • 1996: Splenic Disorders (Paris)
    • 1998: T-cell Lymphomas (Leiden)

SOCIETY FOR HEMATOPATHOLOGY

SH Society Workshops - Guidelines

  1. Panel:

    5-6 people

    Review slides before panel meeting

    • Diagnosis
    • Problems
    • Include/exclude

    Assign each panel member a group of cases to take responsibility for at panel meeting

    Accept 50-60 cases for presentation; 10-20 for "box"

    Organize presentations

    After meeting, each panelist assigned 1 session to moderate

    Take home slides including unstained

    Refine diagnosis - additional stains as needed

    Organize discussion and explain rationale for panel diagnoses

  2. Speakers:

    Talks relevant to categories of cases

    Should not in general be panel members

  3. Case Submission:

    8-10 slides H&E and 8-10 unstained

  4. Priority

    • Meeting attendance

      Accepted cases (one person/case)

      Submitted and not accepted

      Other

    • Slide Sets

      Accepted cases (1/institution)

      Submitted cases

SH Society Workshops - Requirements

  1. Meeting space:

    50-100 people with microscopes

    50-100 people without microscopes

  2. Hotel accommodations:

    100-150 people

  3. Administrative support:

    Credit for Continuing Medical Education

    Registration

    Receipt and organization of slides

  4. Finances:

    Budget proposal presented to Executive Committee

    Registration fees should cover expenses

    External fund raising

    SH will cover 50% of any deficit up to $5000

    Surplus will be split equally between host and SH

  5. Publication:

    The Workshop Panel will prepare a series of articles summarizing the discussions and conclusions of the Workshop. Invited speakers will be asked to submit manuscripts. The proceedings will be published in a journal to be selected by the organizer and the Society (Pathology Patterns or Modern Pathology are suggested).